I was going to use a picture of David Eckstein for this post, because every picture of David Eckstein is golden, but decided that Wally Joyner deserved top billing since he played more games than any other Padre with a pair of twos on his back. Wally World got into 497 games with the Friars -- all while wearing 22 -- from 1996 through 1999. Second place belongs to Xavier Nady, who wore 22 for 269 games with the Padres in 2000 and from 2003 through 2005. Nady came back to San Diego last season for, coincidentally, 22 games but wore 21 during that time because Ian Kennedy already had 22, as he still does.
Other notable Padres to wear 22 include Marcus Giles, Ruppert Jones, Eddie Williams in his first of three stints in San Diego, and inaugural Friar Dick Kelley.